| Athlete | 2025 | 2024 | Difference |
| Rebecca Davis - Lexington HS | 1:23.94 | 1:35.17 | -11.23 |
| Olivia Halsey - Philip Simmons | 1:17.98 | 1:26.64 | -8.65 |
| Shonta Fox - Marlboro County High School | 1:23.38 | 1:30.65 | -7.27 |
| Jalea Stevenson - Marion | 1:21.16 | 1:28.36 | -7.2 |
| Nivea Lomax - Calhoun Falls | 1:12.58 | 1:19.41 | -6.83 |
| Sasha Gilmore - J.L. Mann | 1:15.45 | 1:21.11 | -5.66 |
| Ma'Niyah Lewis - Hartsville | 1:07.28 | 1:12.28 | -4.99 |
| Rachael Parker - Irmo | 1:06.14 | 1:11.13 | -4.99 |
| Ellie Rose Brownfield - Chapin | 1:10.72 | 1:15.59 | -4.87 |
| Gabriela Lagos - Dorman | 1:09.72 | 1:14.27 | -4.55 |
| Deshae'la Neal - Ridge View | 1:07.58 | 1:12.04 | -4.46 |
| Elise Adams - Porter Gaud | 1:18.17 | 1:22.59 | -4.42 |
| Lindsey Powell - Catawba Ridge HS | 1:25.77 | 1:29.22 | -3.45 |
| Amiya Davis - South Pointe | 1:06.37 | 1:09.22 | -2.86 |
| Kaylea Wright - Mauldin | 1:18.00 | 1:20.85 | -2.85 |
| Elizabeth Hydorn - Cardinal Newman | 1:19.87 | 1:22.64 | -2.77 |
| Frankie Wissman - Philip Simmons | 1:15.35 | 1:17.97 |