| Athlete | 2025 | 2024 | Difference |
| Saniyah Rice - Union County | 1:25.51 | 1:41.44 | -15.93 |
| London Russell - South Florence | 1:35.85 | 1:51.74 | -15.89 |
| Xaria Hudson - Fort Dorchester | 1:10.38 | 1:22.59 | -12.21 |
| Adelynne Strother - Lucy Beckham | 1:19.14 | 1:29.33 | -10.19 |
| Shania Anderson - Lower Richland | 1:13.68 | 1:23.21 | -9.53 |
| Kylie Wilson - Landrum | 1:08.02 | 1:16.22 | -8.2 |
| Zion Coping - Strom Thurmond | 1:54.61 | 2:02.81 | -8.2 |
| Trinity Love - Spartanburg | 1:13.56 | 1:21.34 | -7.78 |
| Kandyce Snelson Mathis - St. Johns | 1:14.54 | 1:20.75 | -6.21 |
| Jillian Fickling - Summerville | 1:06.24 | 1:12.42 | -6.18 |
| Lucy Yarborough - Dorman | 1:14.38 | 1:20.45 | -6.07 |
| Jordan Stidem - Strom Thurmond | 1:41.46 | 1:47.21 | -5.75 |
| Hannah Epps - North Central | 1:25.10 | 1:30.75 | -5.65 |
| Zanaria Gist - Boiling Springs | 1:07.62 | 1:13.05 | -5.43 |
| Nyla Fair - White Knoll | 1:15.12 | 1:20.54 | -5.42 |
| Journee McFadden - Wilson | 1:20.68 | 1:25.51 | -4.83 |
| Shamauriah Bethea - Fort Dorchester | 1... |