| Name | 2025 | 2024 | Difference |
| Ty'sean Elmore - Burke | 51.45 | 1:15.30 | -23.85 |
| Reece Singleton - Hammond School | 1:03.08 | 1:20.00 | -16.92 |
| Jordan Hargrave - Lower Richland | 50.13 | 1:06.89 | -16.76 |
| James Daniels - Wagener-Salley | 1:01.19 | 1:17.49 | -16.3 |
| Zion Williams - Thomas Sumter | 56.94 | 1:12.96 | -16.02 |
| TreQuan Patterson - Green Sea-Floyds | 1:04.20 | 1:17.70 | -13.5 |
| Leland Goldsmith - T.L. Hanna | 1:19.24 | 1:31.56 | -12.32 |
| Christopher Jones - South Pointe | 54.71 | 1:06.90 | -12.19 |
| Lucas Hagan - T.L. Hanna | 1:01.73 | 1:13.66 | -11.93 |
| Khamren Wiggins - Colleton County | 53.47 | 1:05.28 | -11.81 |
| Wyatt Gibson - Ashley Ridge | 1:08.67 | 1:20.37 | -11.7 |
| Kemarion Martin - Westside | 55.15 | 1:06.72 | -11.57 |
| Zach Hall - Batesburg-Leesville | 1:00.68 | 1:12.22 | -11.54 |
| Elijah Edwards - Wilson Hall | 1:11.45 | 1:22.90 | -11.45 |
| Braylon Kilpatrick - Seneca | 1:03.44 | 1:14.79 | -11.35 |
| Messiah Swinton - Ashley Ridge | 57.58 | 1:08.89 | -11.31 |
| Elijah Hall - Shannon Forest | 58.96 | 1:09.28 | -10.32 |
| Cayden Evan - Gaffney | 58.58 | 1:08.83 | -10.25 |
| Harlan Brown - St. Johns | 1:05.12 | 1:15.21 | -10.09 |
| Cooper Laroche - Palmetto Christian Academy | 1:00.66 | 1:10.65 | -9.99 |
| Milo Mckee - Por... |