| Alivia Cleveland - Fort Mill | 18:31.95 | 18:35.12 | ( 3.17 ) |
| Nora Brahim - Bishop England | 18:53.25 | 18:44.99 | 8.26 |
| Avah Mallek - Philip Simmons | 18:54.43 | 19:26.93 | ( 32.50 ) |
| Kaylee Rovenstine - Fort Mill | 19:13.04 | 19:05.66 | 7.38 |
| Avery Belk - James Island | 19:13.47 | 19:04.93 | 8.54 |
| Julia Goldman - Lucy Beckham | 19:19.31 | 18:52.99 | 26.32 |
| Annabel Martin - Heathwood Hall | 19:24.98 | 20:29.22 | ( 1:04.24 ) |
| Meredith Norris - Mauldin | 19:44.62 | 19:22.36 | 22.26 |
| Jayda Dyke - Mauldin | 19:47.20 | 19:31.82 | 15.38 |
| Margaret King - Lucy Beckham | 19:49.90 | 21:15.45 | ( 1:25.55 ) |
| Avery Moriarty - Fort Mill | 19:51.57 | 19:48.94 | 2.63 |
| Keatley Sack - Brashier | 20:05.74 | 19:43.93 | 21.81 |
| Mia Zook - Fort Mill | 20:08.03 | 20:27.95 | ( 19.92 ) |
| Mallorie Hogue - Blythewood | 20:09.47 | 19:24.79 | 44.68 |
| Katelyn Bussell - Hanahan | 20:10.89 | 20:35.46 | ( 24.57 ) |
| Kate Paczkowski - Wando | 20:11.06 | 19:43.28 | 27.78 |
| Dorothy Hutchins - Heathwood Hall | 20:12.70 | 19:22.09 | 50.... |