| Ella Nighbor - Clover | 17:55.27 | 19:48.50 | ( 1:53.23 ) |
| Alivia Cleveland - Fort Mill | 17:55.88 | 17:53.88 | 2.00 |
| Avah Mallek - Philip Simmons | 18:15.57 | 18:46.00 | ( 30.43 ) |
| Anna Kelly - Blythewood | 18:17.10 | 18:51.82 | ( 34.72 ) |
| Nora Brahim - Bishop England | 18:29.64 | 17:44.00 | 45.64 |
| Georgia Babcock - Chapin | 18:33.34 | 18:56.98 | ( 23.64 ) |
| Corrie Reinhardt - North Charleston | 18:40.72 | 20:13.02 | ( 1:32.30 ) |
| Acie Vincent - Easley | 18:45.34 | 18:24.77 | 20.57 |
| Callie Rohm - Mauldin | 18:48.36 | 19:23.70 | ( 35.34 ) |
| Keziah Varner - Philip Simmons | 18:54.00 | 19:22.56 | ( 28.56 ) |
| Kaylanna Burroughs - West Florence | 18:55.00 | 19:27.50 | ( 32.50 ) |
| Lowndes Smith - Greer Middle College Charter | 18:55.99 | 19:24.60 | ( 28.61 ) |
| Madelyn Cathey - River Bluff | 18:57.08 | 19:05.17 | ( 8.09 ) |
| Julia McKenna - Hilton Head | 18:57.10 | 21:52.86 | ( 2:55.76 ) |
| Isabella Cardozo - Catawba Ridge HS | 18:57.99 | 19:55.90 | ( 57.91 ) |
| Avery Moriarty - Fort Mill | 18:58.62 | 19:18.97 | ( 20.35 ) |
| Selah Woodworth - Greenville Hurr... |