| Nora Brahim - Bishop England | 17:44.00 | 18:41.17 | ( 57.17 ) |
| Alivia Cleveland - Fort Mill | 17:53.88 | 18:05.00 | ( 11.12 ) |
| Acie Vincent - Easley | 18:24.77 | 19:13.60 | ( 48.83 ) |
| Avah Mallek - Philip Simmons | 18:46.00 | 18:21.45 | 24.55 |
| Anna Kelly - Blythewood | 18:51.82 | 18:24.69 | 27.13 |
| Georgia Babcock - Chapin | 18:56.98 | 18:33.34 | 23.64 |
| Madelyn Cathey - River Bluff | 19:05.17 | 19:18.90 | ( 13.73 ) |
| Jadyn Gandy - Lexington HS | 19:06.46 | 21:09.94 | ( 2:03.48 ) |
| Piper Corrine LeHew - West Ashley | 19:09.64 | 20:34.90 | ( 1:25.26 ) |
| Keatley Sack - Brashier | 19:12.10 | 19:15.08 | ( 2.98 ) |
| Avery Moriarty - Fort Mill | 19:18.97 | 19:00.00 | 18.97 |
| Alice Taylor - James Island | 19:20.85 | 19:37.72 | ( 16.87 ) |
| Keziah Varner - Philip Simmons | 19:22.56 | 18:54.00 | 28.56 |
| Callie Rohm - Mauldin | 19:23.70 | 19:22.10 | 1.60 |
| Lowndes Smith - Greer Middle College Charter | 19:24.60 | 19:54.50 | ( 29.90 ) |
| Kaylanna Burroughs - West Florence | 19:27.50 | 18:55.00 | 32.50 |
| Myla Mason - Wade Hampton | 19:29.... |